Nurofen should not be given to patients with bleeding disorders, cardiovascular disease, peptic ulceration, or a history of such ulceration. Asthma sufferers should only take Nurofen after consulting a doctos. Caution is advised in those paitents who are recieving coumarin anticoagulants. Patients who are sensitive to aspirin should not be give Nurofen. Caution Is required in patients with a history of hypertension and/or heart failure as fluid retention and oedema have been reported in association with NSAID therapy. Elderly: The elderly have an increased frequency of adverse reactions to NSAIDs, especially gastrointestinal bleeding and perforation (PUBs) which may be fatal. The risk of gastrointestinal bleeding or perforation (PUBs) is higher with increasing doses of Nurofen, in patients with a history of ulcers and the elderly. When gastrointestinal bleeding or ulceration occurs in patients receiving Nurofen , treatment with Nurofen should be stopped. Nurofen should be given with caution to patients with a history of gastrointestinal disease (e.g. ulcerative colitis, Crohn's disease, hiatus hernia, gastro-oesophageal reflux disease, angiodysplasia) as the condition may be exacerbated. Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Nurofen should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Angioedema and hypersensitivity reactions have been reported. KEEP OUT OF THE SIGHT AND REACH OF CHILDREN.
